Introduction
Hyaluronic acid has long been considered a miracle weapon in the anti-aging sector. Just one gram can bind up to six liters of water. This means that it gives the skin more elasticity and resilience by acting as a water reservoir. Various types of hyaluronic acid are available on the market. Short-chain hyaluronic acid fragments penetrate relatively deeply into the skin and plump it up from within, while long-chain hyaluronic acid mainly provides long-lasting moisture to the superficial layers of the skin and protects against dehydration.
Sodium acetylated hyaluronate is even more effective. It is considered a real innovation and is the ultimate ingredient for exclusive cosmetic products. But what exactly is acetylation and what makes acetylated hyaluronic acid so special?
How acetylation works
Acetylation is a chemical process in which a hydrogen atom is replaced by an acetyl group. This exchange can take place either at the functional groups (-OH, -SH, -NH₂) or directly at a -C-H bond. An acetyl group refers to the chemical structure -C(O)CH₃. It is composed of the carbonyl and methyl groups and forms the acyl residue of acetic acid. Hence the name: acetyl is derived from the Latin term “acetum” (vinegar).
For example, drugs obtained by acetylation have been known for a very long time. Acetylsalicylic acid (aspirin), obtained in chemically pure form, is certainly the most commonly used preparation in this context. Another example is the acetylation of morphine, which produces heroin (diacetylmorphine). Oxaceprol, a well-known active ingredient used in drugs for degenerative joint diseases such as arthritis, is also obtained through acetylation.
Acetylated hyaluronic acid and its benefits
Sodium acetylated hyaluronate is a highly active ingredient of the latest generation used in exclusive premium anti-aging products.
And with good reason, because it is able to penetrate significantly deeper into the skin than other classic hyaluronic acids. It has both lipophilic and hydrophilic properties. The acetyl group is highly lipophilic, which means that the acetylated hyaluronic acid adheres firmly and significantly reduces evaporation. The skin is moisturized throughout the day.
With the active ingredient sodium acetylated hyaluronate, the first signs of skin aging can therefore be counteracted within a very short time. Thanks to its increased stability against hyaluronidases (degradation enzymes), a long-lasting effect is also guaranteed. Sodium acetylated hyaluronate thus ensures significantly more elastic and supple skin. Damaged and/or rough skin is repaired by a significant improvement in the moisture content of the uppermost layer of the epidermis (stratum corneum).
Studies have shown that the skin elasticity of test subjects increased by 1.6 times after four weeks of regular use (concentration: 0.1 percent sodium acetylated hyaluronate). The skin also appeared noticeably softer and smoother. Furthermore, the study showed that the skin still had a moisture content of 103.4 percent two hours after application. By comparison, test subjects who had used classic hyaluronic acid had a moisture content of 65.3 percent at the same time, and the placebo group had only 29.6 percent. Sodium acetylated hyaluronate keeps the skin well moisturized for a total of twelve hours.
It is ideal for serums, masks, and creams.
Hyaluronic acid profiles
Sodium hyaluronate
International names: Hyaluronic acid, sodium, salt
INCI: Sodium Hyaluronate
CAS number: 9067-32-7
Definition: the sodium salt of hyaluronic acid, a glycosaminoglycan, can be high-molecular or low-molecular
Natural occurrence: among other things, a natural component of the dermis
Effect: binds moisture and preserves skin moisture
Sodium acetylated hyaluronate
International name: Sodium Acetylhyaluronate
INCI: Sodium Acetylated Hyaluronate
CAS number: 287390-12-9
Effect: Compared to classic hyaluronic acid, sodium acetylated hyaluronate has a significantly better ability to retain moisture in the epidermis. Improves skin elasticity, repairs the skin barrier, and has a skin-smoothing effect.
Extraction: through acetylation (see above)
Recommended dosage: 0.01 to 0.1 percent
Sodium hyaluronate crosspolymer
INCI: Sodium Hyaluronate Crosspolymer
International names: Sodium salt, Hyaluronic acid, polymer with 1,1′-sulfonylbis[ethene]
Definition: a hyaluronic acid that adheres to a polymer structure so that it remains in the uppermost layers of the skin for longer, where it improves hydration.
CAS number: 105524-32-1
Effect: reduces transepidermal water loss, moisturizes, increases antioxidant activity.
Hydrolyzed hyaluronic acid
INCI: Hydrolyzed Hyaluronic Acid
CAS number: 9004-61-9
Definition: the hydrolysate of hyaluronic acid obtained by acid, enzymes, or other hydrolysis processes
Effect: penetrates into the lowest layers of the skin to moisturize
Hydroxypropyltrimonium hyaluronate
INCI: Hydroxypropyltrimonium Hyaluronate
Extraction: produced by fermentation
Definition: In addition to the basic properties of hyaluronic acid, such as moisture retention and viscoelasticity, this variant has a special adhesive property, which means that it is not easily washed off.
C12-13 alkyl glyceryl hydrolyzed hyaluronate
INCI: C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate
Effect: Improves the skin barrier, moisturizes the stratum corneum, repairs damaged skin
Conclusion: Sodium acetylated hyaluronate
Acetylated hyaluronate is significantly more effective than classic hyaluronic acid and is the latest innovation in anti-aging. It moisturizes the skin, makes it noticeably smoother and more supple, contributes to greater elasticity, and repairs the skin barrier. Studies have already impressively proven its effectiveness. Sodium acetylated hyaluronate also leaves the skin feeling fresh and does not stick.
For our high-quality private label products, we use the active ingredient sodium acetylated hyaluronate, which meets the highest standards of effectiveness, skin compatibility, and innovation. We combine proven ingredients with modern biotechnological developments to create tailor-made formulations that meet the individual needs of your target group. Our focus is on quality, transparency, and the optimal synergy of all ingredients—for visible results and a compelling brand experience.
Tojo Cosmetics Private Label—your brand, our passion for effectiveness and quality.
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Literature:
The anti-wrinkle properties of sodium acetylated hyaluronate.; Meunier M, et al. J Cosmet Dermatol. 2022. PMID: 34708918
Acetylated hyaluronic acid: enhanced bioavailability and biological studies.;Saturnino C, Sinicropi MS, Parisi OI, Iacopetta D, Popolo A, Marzocco S, Autore G, Caruso A, Cappello AR, Longo P, Puoci F. Biomed Res Int. 2014;2014:921549.
Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy.; Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O. Skin Res Technol. 2016. PMID: 25877232
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals.; Juncan AM, Moisă DG, Santini A, Morgovan C, Rus LL, Vonica-Țincu AL, Loghin F.Molecules. 2021 Jul 22;26(15):4429.